I recently spoke with the previous owner, who bought the house in the early 70s, and he never mentioned having a stoppage when I discussed my plans to remove the cast iron. I've owned the house since 2019.
***EDIT****
I took a closer look at the vertical-to-horizontal transition on the stack from the attic, and I actually have two PVC 1/8 bends instead of the 1/4 bend I thought I saw from the other side of the beam.
At this stage, I want to leave the existing house trap in place since it doesn't appear to have been the source of the problem (I saw no evidence of the stoppage in the RO filter air gap). I do want to replace the cast iron tee with a combo as indicated in the picture. Should I run a long sweep directly out of the 1/8 bend at a) or should I make a jog to the left in the vertical piece after c) to align it with the new combo fitting?