without very precice details my main would go out west side of bulding approx center of bathroom combo laying on side pointed towatrd center of w/c and wyes to pick up tub and lav wet venting along the way , then continue east to laundry room 3x2 combi on back for wash machine , continuing further toward master bath it will need a bit more figureing to pick up kitchen and bathroom probebly a 45 or wye for w/c and when main gets to the wall seperating the house from shop / barn a 3 inch clean out in that wall Maybe think about a shop sink or a 3 inch floor cleanout for a rv dump (I have no idea if an rv dump or 3 inch line in shop makes sence ) or just end all piping at the wall or floor in shop.
the shower will likely require a dry vent from this layout , and the kitchen drain you might want to come up beside window and run a trap arm over to the sink outside the wall but beneath cabinet to avoid drilling studs . but not behind a dishwasher. Im a bit unfamiliar with post and beam barns but if there is no post but a few studs I guess you can drill those if you want as they arent carrying weight?