A tankless system tends to have a moderate amount of internal friction, so not starting out with 50psi, may result in the outlet pressure being lower than you desire.
If you have hard water from your well, you really will want to also install a softener. The burner gets extremely hot in there so that the water can get hot enough while it flies by to be useful...thus causing mineral deposits inside of the heat exchanger. After awhile, worst case, it plugs it up, before that, it becomes much less efficient. Depending on use and how hard your water is, you would want at least an annual demineralization, and it could be more frequently. If you can't do that yourself, that will add significantly to the maintenance costs. While a tank-type WH will have some mineral deposits accumulate as well, you often can flush them out, but even if you don't, it tends to work until it dies - much longer than the demineralization required on a tankless. Plus, you can get parts or a replacement for a tank nearly anytime, anywhere, which may not be possible with the tankless. The home centers are open 7-days a week most places, and while more expensive, any plumber can replace a tank after hours or on the weekend...that may not be possible with a tankless system.
Depending on how deep your well is, year-round, the incoming water could be quite cold. Those volume specs are based on the incoming water being a particular temperature...colder water in, colder water out, or, your acceptable output may need to be throttled back to limit the volume so it can get hot enough along the way.
A quality tank, well insulated is much better than they used to be for standby losses. The actual cost to heat water a specific amount is the same less the burner efficiency discrepancy (depends, that may or may not be a lot), the differences in standby losses won't be. Regardless, you need x amount of BTUs to heat y amount of water, however you heat it. Efficiency, which includes burner and then the standby costs are what differentiate any of the methods.
If the thing will be outside, it will need to have freeze protection either built-in, or you'll have to ensure it can't freeze somehow.