How important is a level toilet? (Toto Vespin intall)

First off, AMAZING site, Terry! I've learned so much lurking here over the past few weeks. In fact, ended up returning a AS Champion to the Borg before opening it and purchased a Toto Vespin with 14" Unifit based on the board's advice. Which brings me to my question:

My bathroom floor is downward sloped away from the wall. The area at the back of my toilet is about 5/8" higher than in front of the bowl. I dry fitted both the toilet and the Unitift adapter. They sit well without any rocking, but there is that distinct slope when I measured for level.

Will this cause me any problems?

If the floor is out of level, it's better if it's the end of the bowl that is low.

It is -- thanks for the advice.