The more pressure drop the PRV needs to do, the quicker it's likely to start to leak and fail. Most have a maximum input pressure, and in worst case scenarios, you may need to reduce pressure in stages with two of them in series. The max input pressure should be in the specs of the PRV. It's the difference between inlet pressure and the adjusted outlet pressure.
Most municipal water supplies don't have a lot of grit in their water, but at least where I live, about once a year, they flush the lines by opening up a bunch of fire hydrants full bore, and the water for the next 10-hours or so tends to be brown with the crud that knocks off of the insides of the main line. That's usually small enough where it will flush through, but not necessarily. They usually announce when that's going to happen. You might want to create your own max flow situation after that to flush your lines internally after it clears up in the supply.
I live in a townhouse. The main water main to our complex is like a 6" diameter pipe. A couple of years ago, we needed to do some maintenance, and found that we couldn't fully close the shutoff/isolation valves. When the plumber inspected, we found that that fine silt had accumulated at the bottom of the pipe and over the years, since the valves had not been used, hardened into almost sedimentary rock...we had to cut out the pipe and install new.
It's not a bad idea to cycle any supply/shutoff valves on occasion to help ensure they'll work when you need them. That silt can accumulate in a PRV, too.
Where I grew up, prior to installing a PRV, the pressure from the utility was enough where it could knock a glass out of your hand when filling it at the sink if you weren't careful! Made washing the shampoo out of your hair easy, though. In a hilly area, the utility may need to supply a pretty high-pressure stream to get the water over the hills and to the customers sitting at the tops of those hills, and more to refill the water towers that tend to sit up high as well. Those at the bottom of the hill can then see some significant pressure.