I dont think anyone actually answered your question. you could run that waterline INSIDE the ductwork if you wanted to. theres no code stopping you from running it next to it, inside it, 2, 10, or 20 feet away from it. As far as heat transfer from the duct work to the cold water, I cant imagine that unless you actually did run the line inside the duct that much if any heat would transfer to the water. And if it did transfer some small amount of heat.... what problem would that be anyway? I think perhaps you are over thinking on this. I cant see your specific situation, but i just cant even imagine how this could be a problem worth worrying about.