Pulling wires in a wall

I believe the rule is max 2 wires per hole when pulling through a stud wall. Can I mix 12g and 8g wires in the holes? The holes for the latter are big, more than 2", and I'd rather just pull an extra wire through those than drilling yet more holes in this wall that carries all the conductors from the main panel.

Thanks.

There is NO "max 2 wires per hole" rule. There are derating rules, and many will argue that pulling through holes in studs does not apply, but IMO that does not matter if you keep to no more than four cables to a hole with up to #10 conductors. There are code reasons for this which I won't go into right now.

I must ask, where are you drilling 2" holes in framing? 2x6 walls? I hope they are dead center.

Thanks.

The holes are in 2x6 walls, it's in a basement so the only load is drywall, maintaining 1-1/4" distance from the edge etc.