Jadnashua
Retired Defense Industry Engineer xxx
A leaded connection is the strongest. And, you'll notice it doesn't even have holes to screw it down to the subfloor, as the metal to metal solid connection should be adequate (but doesn't hurt, and is important if things can move, which shouldnt' happen with CI). The sealing surface must be clean and smooth to install the 'clamping' type flanges. Those require the thing to be anchored to the subflooring (ideally, through the finished floor into the subflooring). It's better to have a full-bore opening if you ever need to use that as a cleanout rather than choking it off, but on a 4" pipe, at the toilet, it shouldn't be an impact as the outlet of a toilet is rarely over 3" (the largest one I know of), and most are closer to 2-1/8" or so.