You will have to find your way around those joists. Even if you have to drop below the joist. When I'm plumbing with 2x8 joists, and I have to go sideways to them, I drop below.
It looks best if you put that near a wall where it can be boxed out. You can run "with" the joists, but when you cross them, drop under.
You're thinking way too much. It isn't going to change physics.