It absolutely makes sense! If you're shutting it down for days at a time, the fuel savings are tremendous!
If your current thermostats are simple-minded types that would be used for any hydronic heating system and not a radiant-specific type and you're satisfied with their performance in your system you can go ahead and use any standard programmable T-stat.
But you may want to wire it in series with a smarter T-stat that has algorithms designed for managing the thermal mass of the slab to avoid big over/undershoots of the desired setpoint, using the programmable thermostat basically as a timer that interrupts the call for heat from the smarter Tekmar or Wirsbo or whatever. There may be programmable timers that could provide the same or better function as the programmable T-stat too, since you'd only be using it for it's time of day/week function. If there is real freeze risk you need a different approach though.