I'd use plywood and make the cutouts as close as possible. Then fill in the gaps around the pipes with spray foam insulation. Make the plywood wider/longer than the hole and use screws to secure it to the sub floor. This doesn't have to look especially pretty.





I have discovered that i have a a problem with mice so I want to seal these gaps. Any suggestions on what to use to cover these? I am sure plywood would work but it seems like I would have trouble cutting it to fit around the plumbing.
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