Manifolds are for people that do not know how to size pipe. You have a bunch of spaggetti running to each fixture from the manifold. It is also impossible to run a recirculation loop and you end up waiting at each fixture for hot water to arrive.
I run branch and trunk lines. Less pipe, neater appearance, recirculation loop from the far end provides instant hot water. In a large home I often use mini manifolds for individual bathroom groups and mount them in a nearby closet.