I have a lot of copper in my garage in barrels that has come out of the homes that you speak of... Its going to take that foul brew they have in their well a long time to eat through the PEX I installed. Water can eat copper better than any mouse could eat PEX.
I'm putting PEX in my addition (3+ bathrooms).
I'm obviously optimistic that the tubing will last. From a material science perspective, the stuff is solid and very inert. If there are going to be problems, I'm willing to bet it will be at the connections. I'm not sure what the logic is that Cu would be less reactive to hard water, Chlorine, etc. I defies my engineering training and my experience as a hydraulic systems engineer.
I initially installed a home store version of PEX connections. Based on outside reviews, comments from this thread, and feedback from a few industrial plumbers who have used the PEX in labs, I changed to WIRSBO. I like the tubing and fittings much better than *******. I strongly recommend the Wirsbo system. It took a few tries to get the hang of it, but the rings are cheap. I have ripped out all other brands of PEX in my system. (I'm not sure what to do with the scrap, maybe a heck of a sprinkler system).
Just to be safe I have used Cu in the walls and PEX in the basement. I actually connect in wall, but I located the connection below the height of the baseboard. If I have to replace a fitting later, the repair damage will be hidden by the baseboard.
I have used a ton of bend supports (Wirsbo brand is the best I have found) to make the system neat. There are not any 'winding bends'. I've also supported the PEX every 24 inches and used suspension clips where the PEX passes through floors and studs. It seemed like it looked a lot neater this way.
My inspector recommended that I place arresters at all stub outs. It seemed like overkill, but I have placed Sioux Chief arresters at all connections.
I use a Manablock manifold. I'm not sure I would recommend this brand again. It just seems flimsy. I like the concept, though.
I did not choose PEX because it was cheaper. I choose PEX because it seemed much easier to run in an old hose with a low head height basement.
Let me know via a private message if you want a recommendation for online vendors I have used.
Steve