Pex Modified Homerun System Design

I have a homerun system design questions for new construction.

Most fixtures are centrally located above utility room (Location of manifold) however, master bathroom, an outdoor shower and a outdoor hose bib are 40' from utility room. All supply lines will be in a heated basement.

I'm working off of two design options.

1. Run all supply lines from the utility room. Just insulate them well.
2. Install a small manifold in a closet near the master bathroom. I am guessing this manifold would be served by the same 3/4 the main manifold is served by. Insulate both supply lines.

I could be splitting hairs here. Just scratching my head for what system will provide best pressure and hot water response time. My house systems are already pretty complex so I would rather stay away from an additional recirculation pump and keep things simple.

Suggestions or comments?

Thanks, Eric

You could go with a supply for each with a remote manifold and add a recirc loop if you wanted.
It's up to you.