Get a masonary bit to drill through the tile. I'm assuming there is wood subfloor below. If so, get long enough flat head wood screws that will anchor into the the wood below the tile. If the subfloor is not wood, there are anchors you can buy that will anchor into harder surfaces. If the tile should crack slightly around the flange, it's not the end of the world. You can use epoxy or silicone to firm it back up because it will be underneath the base of the toilet and won't show. The main concern is that the toilet flange is stable.